解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Polyphyllin Ι is a steroidal saponin isolated from the rhizoma of Paris polyphylla. In the present study, we aimed to investigate the anticancer effects of polyphyllin Ι in colorectal cancer and to elucidate the potential underlying molecular mechanisms. Using, CCK8 assay, flow cytometry, laser confocal microscope ana...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1353512
更新日期:2018-06-01 00:00:00
abstract::Phenolic acids, a sub-class of polyphenols, are widely studied. By contrary, 3,4-dihydroxyphenylacetic acid is scarcely studied. For this purpose, a series of 3,4-dihydroxyphenylacetic acid ester and amide derivatives/conjugates were synthesised for the first time. A systematic study has been performed to quantitative...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1342090
更新日期:2018-06-01 00:00:00
abstract::A new 1,4-napthoquinone derivative, namely (S)-(-)-3-(8-hydroxy-1,4-dioxo-1,4-dihydro-naphthalen-2-yl)-3-(4-hydroxy-3-methoxyphenyl)-propionic acid methyl ester (1), was isolated from the roots of Juglans mandshurica Maxim. The structure was identified based on HR-ESI-MS, 1D and 2D NMR spectroscopic methods. ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1375921
更新日期:2018-05-01 00:00:00
abstract::The use of a matrix solid-phase dispersion (MSPD) process to extract polyphenols from hawthorn (Crataegus oxyacantha L.) a deciduous shrub with an expected rich phytochemical profile, has been evaluated. MSPD extracts of fruits and leaves have an outstanding content of polyphenols, although the particular phenolic pro...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1326040
更新日期:2018-05-01 00:00:00
abstract::A study on essential oil fractions of the Western Balkan endemic Sideritis romana L. subsp. purpurea (Tal. ex Benth.) Heywood collected in Montenegro is reported. The 24-h systematic steam distillation extraction procedure was performed. The gas chromatographic/mass spectrometric (GC/MS) analysis of the fractions show...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1378212
更新日期:2018-05-01 00:00:00
abstract::Plants endue a key role against illnesses caused by oxidative stress. These attributes are frequently associated with polyphenolic compounds. However, presence and concentration of secondary metabolites are affected by abiotic factors. The in vitro culture techniques can solve these drawbacks. Peppers can be a suitabl...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1380026
更新日期:2018-05-01 00:00:00
abstract::In this work, we report a rapid and convenient HPLC-UV-DAD method for the isolation of δ-T3 on semi-preparative scale from two different vitamin E rich processed, commercially available products obtained from the fruits of Elaeis guineensis Jacq. (oil palm) and from the seeds of Bixa orellana L. (achiote tree). Chroma...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1320793
更新日期:2018-05-01 00:00:00
abstract::A new phthalide derivative, xylarphthalide A (1), along with two known compounds (-)-5-carboxylmellein (2) and (-)-5-methylmellein (3), were isolated from the endophytic fungus Xylaria sp. GDG-102 cultured from the Chinese medicinal plant Sophora tonkinensis. Their structures were identified by MS and NMR experiments,...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1311892
更新日期:2018-04-01 00:00:00
abstract::The microbial transformation studies of 7-O-prenylquercetin (1), 4'-O-prenylquercetin (2) and quercetin (3) were investigated with 20 different microbial strains to discover new metabolites. It was revealed that the fungus Mucor hiemalis was the most appropriate micro-organism which was capable of transforming these f...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1367780
更新日期:2018-04-01 00:00:00
abstract::Two new triterpene saponins, albidosides H (1) and I (2), along with the three known saponins were isolated from the barks of Acacia albida. Their structures were elucidated on the basis of extensive 1D- and 2D-NMR studies and mass spectrometry. Albidosides H (1) and I (2) were assayed for their cytotoxicity against H...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1371156
更新日期:2018-04-01 00:00:00
abstract::Known diketopiperazine WIN 64821 and its asymmetric stereoisomers (1-3) had been isolated from the culture broth of a marine gut fungus Aspergillus sp. DX4H. The planar and stereochemistry for new compounds were determined by a suite of techniques including mass, NMR and CD spectra together with Marfey's method. Their...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1363752
更新日期:2018-04-01 00:00:00
abstract::Four fractions were prepared from the crude extract of Caesalpinia minax Hance and the inhibitory activity of nitric oxide (NO) production release of RAW 264.7 cells stimulated by lipopolysaccharide (LPS) was evaluated. The ethyl acetate (EtOAc) fraction showed obvious inhibitory effect. Bioassay-guided fractionation ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1366480
更新日期:2018-04-01 00:00:00
abstract::Triterpene saponins in medicinal plants attract scientific attentions for their structural diversity and significant bioactivities. In this work, a high-performance liquid chromatography coupled to electrospray ionisation and quadrupole time-of-flight mass spectrometry (HPLC-ESI-QTOF-MS/MS) method is used to rapidly s...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1367787
更新日期:2018-04-01 00:00:00
abstract::A phytochemical investigation of Ajuga forrestii Diels led to the isolation of 14 compounds, including eight neo-clerodane diterpenes (1-8), two phytoecdysteroids (9, 11), one stigmastane sterol (10) and three iridoid glycosides (12-14). The structures of these compounds were identified by spectroscopic methods and a ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1371161
更新日期:2018-04-01 00:00:00
abstract::A new chalcone named as balanochalcone (1) together with eight known compounds, methyl caffeate (2), β-hydroxydihydrochalcone (3), methyl gallate (4), dimethyl-6,9,10-trihydroxybenzo[kl]xanthene-1,2-dicarboxylate (5), p-coumaric acid (6), quercetin (7), scopoletin (8) and pinoresinol (9) have been isolated from the et...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1359172
更新日期:2018-04-01 00:00:00
abstract::Naringin, as a component universal existing in the peel of some fruits or medicinal plants, was usually selected as the material to synthesise bioactive derivates since it was easy to gain with low cost. In present investigation, eight new acacetin-7-O-methyl ether Mannich base derivatives (1-8) were synthesised from ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1340280
更新日期:2018-03-01 00:00:00
abstract::Continuing with our study characterising Senecio nutans Sch. Bip., we have isolated and identified a simple coumarin, scopoletin, that could be relevant for the biological properties of the species related with the ancestral medical uses. This is the first report of scopoletin from S. nutans. In addition, the extract ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1335726
更新日期:2018-03-01 00:00:00
abstract::Fourteen wild strains of Staphylococcus aureus positive for gene sea were tested for enterotoxins production and the minimum inhibitory concentration of Leptospermum scoparium, Origanum majorana, Origanum vulgare, Satureja montana and Thymus vulgaris essential oils (EOs) were determined. After this trial, bacteria str...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1338284
更新日期:2018-03-01 00:00:00
abstract::The chemical investigation of whole plants Piper terminaliflorum Tseng led to the isolation of one new furofuran lignan, 7-methoxyasarinin (1), along with three known amide alkaloids (2-4) as N-3,5-dimethoxy-4-hydroxycinnamoylpyrrole (2), dihydropipercide (3) and 1-[(2E,4E,9E)-10-(3,4-Methylenedioxyphenyl)-2,4,9-undec...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1350671
更新日期:2018-02-01 00:00:00
abstract::Cinobufagin (CBF) is an active ingredient isolated from Venenum Bufonis extracted and dried from the secretory glands of Bufo gargarizans Cantor. The purpose of the study was to investigate the effects and underlying mechanisms of CBF on human breast cancer MCF-7 cells in vitro. Our results showed that CBF exhibited o...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1315575
更新日期:2018-02-01 00:00:00
abstract::A total of 205 bluefin and yellowfin tuna samples were examined for mercury detection in order to verify possible differences and have a detailed risk assessment of the two tuna species. The results showed significant higher mercury concentration in muscle tissue of bluefin tuna respect yellowfin tuna (p < 0.001) with...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1309538
更新日期:2018-02-01 00:00:00
abstract::The chemical constituents identified in the essential oils hydrodistilled from the leaves of Amomum gagnepainii T.L.Wu, K.Larsen and Turland and Amomum repoense Pierre ex Gagnep (Zingiberaceae) of Vietnam origin are reported. The chemical analyses were performed by means of gas chromatography-flame ionisation detector...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1346643
更新日期:2018-02-01 00:00:00
abstract::The natural product lupeol 1 was isolated from aerial parts of Vernonia scorpioides with satisfactory yield, which made it viable to be used as starting material in semisynthetic approach. Ten lupeol derivatives 2-11 were prepared by classical procedures. Including, five new esters derivatives 7-11, which were obtaine...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1353982
更新日期:2018-02-01 00:00:00
abstract::Chemical investigation of the root bark of Morus alba led to the isolation of a new flavone, dioxycudraflavone A (1) and a new 2-arylbenzofuran, 5-hydroxyethyl moracin M (2), together with seven known compounds namely sanggenon V (3), morusin (4), morusignin L (5), licoflavone C (6), moracin C (7), alfafuran (8) and m...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1327862
更新日期:2018-01-01 00:00:00
abstract::The chemical composition of the essential oil (EO) obtained from the aerial parts of Rydingia michauxii (Briq.) Scheen & V.A. Albert was analysed by gas chromatography and gas chromatography/mass spectrometry (GC/MS). Eighty components were identified in the oil with caryophyllene oxide (20.1%), trans-verbenol (10.2%)...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1343321
更新日期:2018-01-01 00:00:00
abstract::A new malyngamide (1) was isolated along with seven known compounds (2-8) from the marine cyanobacterium Moorea producens collected in Hawaii. Compound 1 represented the first reported malyngamide with a hydroxy moiety at C-7 of the characteristic fatty acid portion of the compound. Compound 1 showed cytotoxicity agai...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1338282
更新日期:2018-01-01 00:00:00
abstract::Nine lupeol derivatives were synthesised and assayed in vitro for their antitumour activities against three human tumour cells lines, A549, LAC and HepG2. Of lupeol derivaties, six were new compounds, and five compounds against A549 cells, four compounds against HepG2 cells and three compounds against LAC cells were e...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1329729
更新日期:2018-01-01 00:00:00
abstract::The chemical composition of the essential oils isolated from the aerial parts of Anthemis arvensis L. subsp. arvensis, Anthemis cretica subsp. messanensis (Brullo) Giardina & Raimondo and from flowers and leaves of Anthemis cretica subsp. columnae (Ten.) Frezén were determinated by GC-FID and GC-MS analyses. Torreyol ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1297444
更新日期:2017-12-01 00:00:00
abstract::The composition and antibacterial activity of the essential oil of the aerial flowering parts of Nepeta hormozganica Jamzad have been studied. Analysis of the oil was conducted by GC-FID and GC-MS. Thirty-two components were characterized accounting for 99.4% of the total oil. Oxygenated monoterpenes (87.5%) were foun...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1295237
更新日期:2017-12-01 00:00:00
abstract::The ethanolic extract of the leaves of Eriobotrya japonica exhibited inhibitory activity against phosphodiesterase-4D (PDE4D), which is a therapeutic target of inflammatory disease. Subsequent bioassay-guided fractionation led to the isolation of a new triterpene (1), together with seven known triterpenoids, methyl co...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1300796
更新日期:2017-12-01 00:00:00
abstract::Magnolia grandiflora (Magnoliaceae) is an evergreen tree with fragrant and showy flowers native to southeastern USA but widely cultivated all over the world and used in cosmetics industry in treatment of skin diseases. Here, we report on the chemical analysis of the essential oil obtained from flowers of plants cultiv...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1303699
更新日期:2017-12-01 00:00:00
abstract::Antioxidant, anticholinesterase and antidiabetic activities of three curcuminoids isolated from the Curcuma longa were simultaneously tested and compared in this study. The highest antioxidant power was detected for curcumin with the applied methods. The drug potentials of curcuminoids for Alzheimer's disease were con...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1299727
更新日期:2017-12-01 00:00:00
abstract::Cynanchum acutum L. subsp. sibiricum (Willd.) Rech. f. was extracted with hexane, acetone, methanol and water individually. A sample was heated in water then extracted with ethyl acetate. Among the extracts, the ethyl acetate extract exhibited the most antiproliferative activity, so isolation of bioactive compounds wa...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1289201
更新日期:2017-11-01 00:00:00
abstract::One new iridoid glycoside, 6',10-di-O-(4-hydroxybenzoyl) aucubin (1), together with ten known compounds, including five diterpenoids (2-6), two triterpene glucosides (7-8) and three methoxylated flavonoids (9-11) were isolated from the fruits of Vitex rotundifolia. Compounds (3, 4, 7, and 8) were reported for the firs...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1314284
更新日期:2017-11-01 00:00:00
abstract::Phytochemical study on the 95% ethyl alcohol extract of stems of Chenopodium ambrosioides resulted in the isolation of two new polyol monoterpenes, 4-hydroxy-4(α or β)-isopropyl-2-methyl-2-cyclohexen-1-one (1) and 1-methyl-4β- isopropyl-1-cyclohexene-4α,5α,6α-triol (2), together with five known compounds, (1S,2S,3R,4S...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1314278
更新日期:2017-11-01 00:00:00
abstract::A new resin glycoside, named calysolin XVIII (1), was isolated from the leaves, stems and roots of Calystegia soldanella Roem. et Schult. (Convolvulaceae). The structure of 1 was defined as 11S-jalapinolic acid 11-O-β-d-glucopyranosyl-(1 → 3)-O-(2-O-2S-methylbutyryl,4-O-3-hydroxy-2-methylenebutyryl)-α-l-rhamnopyranosy...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1280492
更新日期:2017-11-01 00:00:00
abstract::A phytochemical investigation of the MeOH extract of twigs and leaves of Tephrosia preussi was carried out to give a new kaempferol triglycoside, named tephrokaempferoside (1), together with five known compounds: tephrosin (2), betulinic acid (3), lupeol (4), β-sitosterol (5) and 3-O-β-d-glucopyranoside of β-sitostero...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1315720
更新日期:2017-11-01 00:00:00
abstract::The aim of study was to compare the content of phenolic acids and flavonoids in two cultivars of Lavandula angustifolia: 'Blue River' and 'Ellagance Purple', including flowers and leafy stalks. Total phenolics and total flavonoids contents were determined by UV-Vis spectroscopy. The contents of total phenolics in leaf...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1320792
更新日期:2017-11-01 00:00:00
abstract::A new benzophenone glycoside, mitraphenone A (1), together with three known compounds (2-4) were isolated from the leaves of the traditionally used medicinal plant Mitracarpus villosus (Rubiaceae) collected in Nigeria. A combination of one- and two-dimensional NMR spectroscopic and mass spectrometric measurements were...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1306701
更新日期:2017-10-01 00:00:00
abstract::One new tirucallane-type nortriterpenoid Nortirucallane A (1), together with Chrysoeriol (2) and Isorhamnetin (3), was isolated from the methylene chloride part of Lonicerae japonicae flos. Their structures were elucidated by the detailed analysis of comprehensive spectroscopic data. Compound 3 was isolated from the g...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1299731
更新日期:2017-10-01 00:00:00